Kari Coleman's career began in 1992 when she starred in the series In Living Color. Following that she starred in shows such as The Jamie Foxx Show, Home Improvement, Roseanne, Married...with Children, and Seinfeld.
In 2005, Coleman began a year long role as Deborah Hauser in Veronica Mars.
Recently, Coleman has starred as Mrs. Stone in Zach Stone Is Gonna Be Famous in 2013 and also played a role in Switched at Birth.
In 2012, she played Helen Stacy in The Amazing Spiderman. In 2014, she reprised this role in The Amazing Spider-Man 2.
Coleman married fellow actor Kyle Secor in 2002. Together, the two have two children.